BioCAS 2016|Oct.17-19|Shanghai,China
Prof. Sandro Carrara

Sandro Carrara

Biography:

Sandro Carrara is an IEEE Fellow for his outstanding record of accomplishments in the field of design of nanoscale biological CMOS sensors. He is a faculty member (MER) at the EPFL in Lausanne (Switzerland). He is former professor of optical and electrical biosensors at the Department of Electrical Engineering and Biophysics (DIBE) of the University of Genoa (Italy) and former professor of nanobiotechnology at the University of Bologna (Italy). He holds a PhD in Biochemistry & Biophysics from University of Padua (Italy), a Master degree in Physics from University of Genoa (Italy), and a diploma in Electronics from National Institute of Technology in Albenga (Italy). His scientific interests are on electrical phenomena of nano-bio-structured films, and include CMOS design of biochips based on proteins and DNA. Along his carrier, he published 7 books, one as author with Springer on Bio/CMOS interfaces and, more recently, a Handbook of Bioelectronics with Cambridge University Press. He also published more than 200 scientific papers and is author of 12 patents. He is now Editor-in-Chief (Associate) of the IEEE Sensors Journal; he is also founder and Editor-in-Chief of the journal BioNanoScience by Springer, and Associate Editor of IEEE Transactions on Biomedical Circuits and Systems. He is a member of the Board of Governors (BoG) of the IEEE Circuits And Systems Society (CASS). He is member at large of the IEEE Sensors Council. He has been appointed as IEEE CASS Distinguished Lecturer for the years 2013-2014. His work received several international recognitions: several Top-25 Hottest-Articles (2004, 2005, 2008, 2009, and two times in 2012) published in highly ranked international journals such as Biosensors and Bioelectronics, Sensors and Actuators B, IEEE Sensors journal, and Thin Solid Films; a NATO Advanced Research Award in 1996 for the original contribution to the physics of single-electron conductivity in nano-particles; three Best Paper Awards at the IEEE PRIME Conference in 2015 (Glasgow), in 2010 (Berlin), and in 2009 (Cork), a Best Poster Award at the Nanotera workshop in 2011 (Bern), and a Best Poster Award at the NanoEurope Symposium in 2009 (Rapperswil). He also received the Best Referees Award from the journal Biosensor and Bioelectronics in 2006. From 1997 to 2000, he was a member of an international committee at the ELETTRA Synchrotron in Trieste. From 2000 to 2003, he was scientific leader of a National Research Program (PNR) in the filed of Nanobiotechnology. He was an internationally esteemed expert of the evaluation panel of the Academy of Finland in a research program for the years 2010-2013. He has been the General Chairman of the Conference IEEE BioCAS 2014, the premier worldwide international conference in the area of circuits and systems for biomedical applications.

Talk Title: System-In-Package and System-On-Chip for Remote Monitoring of Human Metabolism

Talk Abstract:

Integrated electrochemical Nano-Bio-Sensors [1] for diagnosis and/or treatment of patients with specific physiological conditions (e.g., heart, cardiovascular, cancer diseases) or convalescents is a key factor to provide better, more rationale, effective and ultimately low-cost health care also at home. The ultimate goal of improved health care on those subjects is the extension of the patients' autonomy, the possibility for auto-monitoring, the improvement of their comfort levels and their integration into everyday life. Some systems for on-line monitoring are available in the market. They use wearable devices (accelerometers, heartbeat monitoring system, etc). However, all these systems do not measure the human metabolism at molecular level (metabolites). The only available real-time, implantable/wearable systems for metabolic control are limited to glucose monitoring and used only for diabetic patients. However, electrochemical sensors may address so many other molecules, which have crucial relevance in human metabolism in chronic patients. So far, there are no available integrated nano-bio-systems for multi-metabolites, real-time, remote monitoring of the human metabolism. Thus, the aim of this tutorial is to present innovative concepts for multi-panel, highly integrated, fully implantable, remotely powered and real-time monitoring systems for human metabolism at molecular level. The considered metabolic molecules will be glucose, lactate, glutamate, ATP [2], and anticancer drugs as well as anti-inflammatory ones [3]. In case of drugs, the specificity of electrochemical sensors is improved at system level [4]. The proposed nanotechnology will be based on carbon nanotubes to improve the sensors performance [3, 5]. To pursue their detection, innovative VLSI solutions [6] are discussed including the system remote powering [7]. The new approach is demonstrated by showing Systems-In-Package with embedded System-On-Chip that integrate: (i) a sensors array for data acquisition; (ii) remote power and/or data transmission; (iii) nano-sensors; CMOS IC design; (iv) multi-panel metabolites detection. Systems applications are shown in the field of implantable devices with in-vivo experiments too [8] by including packaging issues [9] and monitoring in intensive care units [10].

Bibliography:

  1. [1] Sandro Carrara (Ed), Nano-Bio-Sensing, Springer, New York, 2010, ISBN 978-1-4419-6168-6
  2. [2] Sandro Carrara, Léandre Bolomey, Cristina Boero, Andrea Cavallini, Eric Meurville, Giovanni De Micheli, Fabio Grassi, Tanja Rezzonico, Single-Metabolite Bio-Nano-Sensors and System for Remote Monitoring in Animal Model, proceedings of the IEEE Sensors Conference 2011
  3. [3] Sandro Carrara, Andrea Cavallini, Victor Erokhin, Giovanni De Micheli, Multi-panel drugs detection in human serum for personalized therapy, Biosensors and Bioelectronics, 26 (2011) 3914-3919
  4. [4] Camilla Baj-Rossi, Giovanni De Micheli, Sandro Carrara, Electrochemical Detection of Anti-Breast-Cancer Agents in Human Serum by Cytochrome P450-Coated Carbon Nanotubes, Sensors 12 (2012) 6520-6537
  5. [5] Cristina Boero, Maria Antonietta Casulli, Jacopo Olivo, Eric Orso, Marco Mazza, Sandro Carrara, Giovanni De Micheli, Design, development and validation of an in-situ biosensor array for metabolite monitoring of cell cultures, Biosensors and Bioelectronics, 61 (2014) 251-259
  6. [6] Sara S. Ghoreishizadeh, Camilla Baj-Rossi, Andrea Cavallini, Sandro Carrara, and Giovanni De Micheli, An Integrated Control and Readout Circuit for Implantable Multi-Target Electrochemical Biosensing, IEEE Transaction on Biomedical Circuit and Systems, TBCAS 8(2014) 891-898
  7. [7] Jacopo Olivo, Sandro Carrara, and Giovanni De Micheli, A study of Multi-Layer Spiral Inductors for Remote Powering of Implantable Sensors, IEEE Transactions of Biomedical Circuits and Systems TBCAS 7(2013) 536-547
  8. [8] Sandro Carrara, Camilla Baj-Rossi, Sara Seyedeh Ghoreishizadeh,Stefano Riario,?Grégoire Surrel, Francesca Stradolini, Cristina Boero, Giovanni De Micheli, Enver G. Kilinc, Catherine Dehollain, Full System for Translational Studies of Personalized Medicine with Free-Moving Mice, invited paper accepted for presentation at ISCAS 2015
  9. [9] Camilla Baj-Rossi, Enver G. Kilinc, Sara S. Ghoreishizadeh, Daniele Casarino, Tanja Rezzonico Jost, Catherine Dehollain, Fabio Grassi, Laura Pastorino, Giovanni De Micheli and Sandro Carrara, Full Fabrication and Packaging of an Implantable Multi-panel Device for Monitoring of Metabolites in Small Animals, IEEE Transaction on Biomedical Circuit and Systems, TBCAS 8(2014) 636-647
  10. [10] Flavia Basilotta, Stefano Riario, Francesca Stradolini, Irene Taurino, Danilo Demarchi, Giovanni De Micheli, Sandro Carrara, Wireless Monitoring in Intensive Care Units by a 3D-Printed System with Embedded Electronic, IEEE BioCAS 2015, Atlanta (Georgia - US), pp. 133-136

Sponsors:

IEEE Circuits And Systems Society Engineering Medical Biology Socierty Solid-State Circuits Society IEEE Brain Community Shanghai Jiao Tong University Hangzhou Dianzi University